Placental Angiotensin Receptor Type 1 by Ubiquitination-Preventing Isopeptide Tissue Transglutaminase Contributes to the Pathogenesis of Preeclampsia and Stabilizes
نویسندگان
چکیده
pia au to riz ad a p or CD R Jianping Jin, Rodney E. Kellems and Yang Xia Chen Liu, Wei Wang, Nicholas Parchim, Roxanna A. Irani, Sean C. Blackwell, Baha Sibai, Modification Placental Angiotensin Receptor Type 1 by Ubiquitination-Preventing Isopeptide Tissue Transglutaminase Contributes to the Pathogenesis of Preeclampsia and Stabilizes Print ISSN: 0194-911X. Online ISSN: 1524-4563 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Hypertension doi: 10.1161/HYPERTENSIONAHA.113.02361 2014;63:353-361; originally published online November 4, 2013; Hypertension. http://hyper.ahaj urnals.org/content/63/2/353 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://hyper.ahajournals.org/content/suppl/2013/11/04/HYPERTENSIONAHA.113.02361.DC1.html Data Supplement (unedited) at:
منابع مشابه
Tissue transglutaminase contributes to the pathogenesis of preeclampsia and stabilizes placental angiotensin receptor type 1 by ubiquitination-preventing isopeptide modification.
Preeclampsia is a life-threatening pregnancy disorder that is widely thought to be triggered by impaired placental development. However, the placenta-related pathogenic factors are not fully identified, and their underlying mechanisms in disease development remain unclear. Here, we report that the protein level and enzyme activity of tissue transglutaminase (TG2 or tTG), the most ubiquitous mem...
متن کاملHypoxia-independent upregulation of placental hypoxia inducible factor-1α gene expression contributes to the pathogenesis of preeclampsia.
Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial response to hypoxia, whereas chronically elevated HIF-1α is associated with multiple disease conditions, including preeclampsia, a serious hypertensive disease of pregnancy. However, the molecular basis underlying the persistent elevation of placental HIF-1α in preeclampsia and its role in the pathogenesis ...
متن کاملP-218: Investigation of Association between Angiotensin II Type 1 and 2 Receptor (AT1R & AT2R) Gene Polymorphisms and Susceptibility to Pre-Eclampsia (PE) in Iranian Women
Background: Hypertension during pregnancy period along with the presence of protein in the urine, after the 20th weeks of gestation is called preeclampsia (PE). About five percent of all pregnancies are manifested with PE and its exact etiology has still remained unknown. The renin-angiotensin system (RAS) has an important role in the regulation of blood pressure during pregnancy and so pathoph...
متن کاملDrug Therapy for Small Abdominal Aortic Aneurysm
Dear Editor,Abdominal aortic aneurysm is often asymptomatic, less recognized, and causes considerable mortality and morbidity, if missed. The incidence varies from country to country and the occurrence is influenced by modifiable (smoking, coronary heart disease, hypertension, dyslipidemia, and prolonged steroid therapy) and non-modifiable risk factors (increasing age, male gender, and positive...
متن کاملAutoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia.
Preeclampsia (PE) is a prevalent life-threatening hypertensive disorder of pregnancy associated with increased complement activation. However, the causative factors and pathogenic role of increased complement activation in PE are largely unidentified. Here we report that a circulating maternal autoantibody, the angiotensin II type 1 receptor agonistic autoantibody, which emerged recently as a p...
متن کامل